Cipro-induced Vascular Ehlers-Danlos Syndrome

Because of the funky vascular responses in my hands and feet, and the changes in my veins, I’ve suspected that Cipro caused vascular problems, and since I’ve been looking for journal articles on Cipro’s effects on collagen gene expression, I’ve begun to suspect that higher doses of Cipro induces a connective tissue disease that is identical, for all intents and purposes, to Vascular Ehlers-Danlos Syndrome.

Here’s what I have so far…

The effect of aging on migration, proliferation, and collagen expression of tenocytes in response to ciprofloxacin

“Ciprofloxacin-mediated inhibition of tenocytes migration was much more significant in old tenocytes treated with 50 µg/ml of ciprofloxacin.”

“gene expression of type I collagen remained unchanged in young and old tenocytes with or without ciprofloxacin treatment. However, the gene expression of type III collagen decreased in either young or old tenocytes treated with 50 µg/ml of ciprofloxacin.”

“protein expression of type III collagen decreased in both young and old tenocytes treated with 50 µg/ml of ciprofloxacin.”

Ciprofloxacin has antifibrotic effects in scleroderma fibroblasts via downregulation of Dnmt1 and upregulation of Fli1

“at the highest dose tested (100 μg/ml), ciprofloxacin potently downregulated collagen type I protein (>60%) in both normal and SSc dermal fibroblasts. Ciprofloxacin also inhibited mRNA expression of COL1A1 and COL1A2, displaying a similar dose response…”

“ciprofloxacin increased MMP1 production in human dermal fibroblasts. Additionally, there was a significant decrease in CCN2 protein levels after antibiotic treatment…”

“Ciprofloxacin significantly induced Erk1/2 phosphorylation in human dermal fibroblasts, with the levels of P-Erk1/2 almost doubling, suggesting that Erk1/2 may be involved in ciprofloxacin-induced MMP1 gene expression.”

Ciprofloxacin up-regulates tendon cells to express matrix metalloproteinase-2 with degradation of type I collagen

“The results of real-time RT-PCR revealed that gene expression of MMP-2 was up-regulated by ciprofloxacin dose-dependently.”

MMP-2 up-regulation isn’t a great thing, as it’s found in cases of abdominal aortic aneurism. (Ubiquitous Elevation of Matrix Metalloproteinase-2 Expression in the Vasculature of Patients With Abdominal Aneurysms)