Magickal Manganese

It’s been a while since I posted. The reason is, life’s been a lot better. My brain is sharper. I have more energy. I even started cleaning my house.

I had a bit of set-back with my endocrinologist, who I was sent back to because the excessive thirst, polyuria and nocturia have not resolved. He attempted to diagnose me with “psychological thirst” and I left his office in a rage. I’ve worked too long and too hard fighting this condition to put up with anyone telling me that I created this problem by drinking too much water. For one thing, if nocturia is present, a diagnosis of psychological thirst should never be made. Secondly, the thirst started at the same time I started having to urinate every 30 minutes and was getting up every 3 hours at night to use the bathroom, and coincided with hair loss and other problems. Thirdly, I don’t have any of the mental health conditions that would cause excessive water drinking.

So, I was back to working on the puzzle alone, fighting off migraines by drinking a gallon of water a day and eating lots of salty foods. I transferred to an integrative health clinic, and my new doctor tested my vasopressin level. It was low — low enough that I need more tests to determine if it was a fluke or if I have a mild case of diabetes insipidus.

While waiting for more tests to be arranged, on a whim last month I picked up a case of C2O coconut water. I was drinking it here and there, and noticing that I felt less dessicated the next day… so I tried drinking it every day for a week and the horrible, maddening thirst subsided a bit.

I got curious. What in C2O could be affecting me so? The only thing on the dietary information panel that stuck out was manganese. I hadn’t run across a single mention of manganese in any of the support groups I frequent, so I started digging.

What I found is very interesting:

  1. Manganese chelates fluoroquinolones, especially ciprofloxacin! That means when you take a FQ drug, all the manganese in your body is going to bind with it, just like happens with magnesium and other trace minerals, and your body will dump it as waste.
  2. Manganese detoxifies your mitochondria!
  3. Manganese is necessary for endocrine function!
  4. Manganese is also a necessary nutrient for wound healing… in other words, you can’t make collagen without it.

While my nerves and mind and gut have healed significantly, my tendons have continued to deteriorate. I just ordered a walker, and I’m supposed to buy expensive, moldable shoe inserts to take the pressure off my sesamoid bones, because the tendons attaching them to my feet cannot handle my own body weight. I’ve continued to watch my muscles waste away.

Now I’m wondering, could all of this come down to another, lesser-known deficiency? Could my pain and suffering be caused by cipro extracting this vital mineral from my body, and my ignorance that I’d need to supplement to restore it? I’m about to find out, as I’ll be supplementing for the next couple of months. I haven’t yet settled on a supplement level, and won’t for a couple of weeks until I see my doctor again, but for now I’ll settle for something around the RDA, since half that amount has been enough to make a noticeable difference.

Here’s a nice general info page on manganese, including its interactions with other minerals (seems like it’s best to take it alone rather than with things like magnesium and calcium).

Day 34: Reduced Calorie Fasting

I saw my doc today and we discussed my research on fasting because I need to know I’m on the right track with my thoughts on forcing my damaged cells to self-destruct.

Everyone has been suggesting to me that I take in nothing but water when I fast, and it just doesn’t feel right when I think about how we evolved and how our bodies work. Zero calorie fastng sounds like something a healthy person can do for a quick reboot, but not a good idea for someone whose cells can’t even produce enough energy to make it through a day. I explained to her what I’ve been researching, and she agreed with me that zero calories is not a good idea for someone as sick as me. We talked about a couple of interesting studies, and based on them she wants me to do reduced calorie fasting at 600 calories a day, as long as I want, but I have to calorie-load a couple of days a week. So, I can fast 5 days and then eat as much as I want for 2 days, and take ALL my supplements because a lack of cell-building nutrients won’t be good while I’m trying to heal my cells.

I then presented to her my hypothesis that the reason I got so sick around 18 months after being given the Cipro is because too many of my cells were damaged, because fluoroquinolones cleave to human DNA and are phototoxic, so the damage continued until my body decided to shut down and try to repair itself, which is why I lost my appetite… it’s like my body wanted to heal and forced me into cell regeration mode… but I was not detoxing at the time because I had no idea I’d been poisoned, so while my body was killing off a lot of cells, I could not clear the waste and got really sick. My liver, spleen and lymph nodes all swelled up and I only started to get better when I started nutrient loading and detoxing, as well as treating viral infections that had been in remission and all became active post-flox. She listened to my presentation, punctuated with my references to medical studies, and told me that in the absence of any other explanation (and there is none, that she is aware of), my hypothesis makes perfect sense!

So, I will now proceed with trying out a fasting cycle that is 3-5 days a week at 600 calories a day. I’m going to have to use a calorie tracker while I get the hang of it. I’m also going to make a concerted effort to keep on the detox regimen until I feel that my body has replaced most of my broken cells.

Then, hopefully, I will be able to get adipose stem cell therapy to repair my tendons.

Day 27: Fasting to Provoke DNA Repair

In my support group, several articles came through the newsfeed on the DNA repair cycle that reduced caloric intake provokes in humans.

I think my body naturally tried to do this last winter about 18 months post-flox. I lost my appetite and then I got really sick, I think because I was completely ignorant of what was happening, so I was not supporting my body when it was trying really hard to repair my cells. Because flouroquinolones cause a lot of DNA damage, I think I was losing a lot of cells. I became weak and my I had tremors. My liver and spleen swelled up and all the lymph nodes on my right side and I ended up in the ER twice with what I now think was toxicity from cell die off that my body could not clear out. Even though my labs were off my liver swollen, they sent me home with “anxiety” once and “fibromyalgia” the other.

I want to try that again, but more gently. I’m trying to figure out how much of a caloric reduction is necessary, so that I can provoke cell repair but not in a way that will overwhelm my ability to clear the toxic by-products. It’s also difficult to go completely without nourishment when you’re weak. I’m not convinced we have to reduce calories to zero, but most people who’ve responded to my questions believe I must reduce my caloric intake to zero. While I wait for an opportunity to talk to my primary care doc, I will proceed much as I did this past week.

The fast I just finished wasn’t as successful as I wanted. I needed a couple of days of rest and thought I’d have it when my kid went to a campout, but they got rained out and it ended up being more stressful than I wanted, but I managed 48 hours with 400 calories each 24 hour period. I would have made it to 60 hours if it wasn’t for that bowl of oatmeal.

Next time I want to do a coffee enema as I start the fast, maybe one when I end it, and depending on what I find out from my doctor, somewhere between zero and 400 calories each 24 hours… I’d at least like to drink my turmeric, cinnamon, modified citrus pectin tea with a splash of half and half a couple of times a day. Maybe I’ll make it past 2 days next time, but I think gentle is the way to go for a few months. I was in a great deal of pain last night, but for two days in a row I’ve now woken up without quite as much pain in my extremities.

I also need to figure out what supplements should be cut out during a fast. I don’t want to skip the ones needed for DNA repair, or the ones my tendons need, since they’re expremely delicate.

I have a feeling it will be a slow process.

Day 11: Black Garlic

In my heavy research phase into antioxidants to combat the damage done by Cipro, I read about black garlic. I immediately got out my rice cooker and dumped every bulb of garlic I’d harvested from my garden, plus the bulbs I’d purchased at my co-op.

I have now sampled 2 out of the 3 varieties I stuck in my rice cooker, and I can tell you that the purple varieties are WAY TASTIER than the porcelain varieties. I don’t like to cook with the purples because the bulbs are smaller and harder for my damaged hands to peel, but they are perfect for black garlic and peel more easily after being in the rice cooker than the porcelain bulbs do… and now I’m eating the little cloves like candy.

I haven’t sampled the elephant garlic yet… it’s technically not a garlic, it’s a leek, but it’s also high in allicin so it should work.

Why make black garlic?

Physicochemical and Antioxidant Properties of Black Garlic

The Analysis of Saccharide in Black Garlic and its Antioxidant Activity