Probiotics for MS

A friend asked me how to help her compromised gut without going as far as using fecal matter or breast milk to replace species that have been found to be compromised in people with MS, and because MS is an inflammatory disease, I decided it would be useful to have a list of probiotics that can be purchased that might decrease the severity of inflammatory diseases, if not prevent them. Working off the published study, I went looking for products that contain the compromised species, or a strain that plays a similar role. Where I could find them, I’ve linked the products with my Amazon associate number, because if you buy from Amazon, you help me get the supplements I need, too. Get them where it’s convenient for you, though. This was just my disclosure that buying through some of  the links will benefit me 🙂

When taking probiotics, take them with a high-fiber diet, and rotate through them. Eat naturally fermented foods. You don’t need to take every probiotic every day. If you tailor your diet to provide plenty of soluble (prebiotics and resistant starch) and insoluble fiber, you’ll be able to build a sustainable and healthy gut profile over time. If you want to get really sciencey about fiber, read this.

I’ll also note if my FMT/human breast milk treatments introduced a species, although my microbial analysis does not provide the specific strain in every case… and I promise to post my thoughts on my “before” and “after” microbiota profiles as soon as I’m done analyzing them, as there were some changes. I also want to note that many of the species listed here are anaerobic, which means that “miracle cures” like Mineral Miracle Supplement, which introduce oxygen to the gut, will kill beneficial species.

The article my friend asked me to look at was this one: Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters

The study found “… a depletion of 19 species was striking in MS samples, and fourteen of them belonged to Clostridia clusters XIVa and IV” and “also found a reduction in the proportion of several Bacteroides” (which are also reduced in the guts of people with IBD).

Here they are, with any useful information I could dredge up.

Faecalibacterium prausnitzii: no replacement available, although this study found that consumption of Bacillus coagulans GBI-30 increased the f. prausnitzii population. Bacillus coagulans GBI-30 is patented and can be found in Life Extension Florassist Oral Hygiene Lozenges and Schiff Digestive Advantage.

Anaerostipes hadrus: not available in supplement form. I did pick up an Anaerostipes strain from either FMT or HBM.

Eubacterium rectale ATCC 33656: not available in supplement form.

Clostridium sp.: we’re talking Clostridium species in general… there are a handful that will make you horribly sick if they crowd out beneficial microbes, but the genus is largely beneficial. You can get a beneficial strain in Advanced Orthomolecular Research AOR, Advanced Series, Probiotic-3.

Specifically mentioned in the study – Clostridium sp. RT8, Clostridium sp. ID5: Not available in supplement form. However, of note : Phytonutrient diet supplementation promotes beneficial Clostridia species and intestinal mucus secretion resulting in protection against enteric infection.

butyrate-producing bacterium SL7/1, butyrate-producing bacterium A2-175: Not available in supplement form, but I found one clinically-studied butyrate-producing bacteria (Lactobacillus rhamnosus GG) product on the market, Culturelle Health & Wellness Probiotic in addition to Advanced Orthomolecular Research AOR, Advanced Series, Probiotic-3.

Bacteroides stercoris, Bacteroides coprocola, Bacteroides coprophilus: Bacteroides are so sensitive to exposure to air that they cannot at this time be put in supplements. However, a study found that echinacea will naturally increase your Bacteroide population. Not all Bacteroides are beneficial, so proceed with caution. I had approximately 5x more Bacteroides after FMT/HBM.

Lactobacillus rogosae: Not available in supplement form. However, The Scientific Basis for Probiotic Strains of Lactobacillus examines other strains of benefit. Culturelle Health & Wellness Probiotic contains Lactobacillus rhamnosus GG. Jarrow Formulas FemDophilus contains Lactobacillus rhamnosus GR-1. Garden of Life Once Daily Ultra contains Lactobacillus acidophilus NCFM. BioGaia ProTectis drops D3  and Pedia-Lax Probiotic Yums contain L. reuteri MM53, which is now known as L. reuteri protectis. Asian markets carry a product called Yakult which contains L. casei Shirota.

Lachnospira pectinoschiza: patented in 2012 but not yet available in supplement form.

Roseburia sp.1120: Not available in supplement form.

Clostridiaceae bacterium SH032: Not available in supplement form.

Sutterella wadsworthensis 2_1_59BFAA: Not available in supplement form.

Desulfotomaculum sp. CYP1: Not available in supplement form.

Prevotella copri DSM 18205: Not available in supplement form… and nor does it seem that P. copri is beneficial as it’s been linked to RA… so the result of this study is interesting indeed and hopefully more research will be done. Incidentally, I had no detectable Prevotella strains prior to FMT/HBM, but picked up a small amount in the process.

Megamonas funiformis YIT 11815: Not available in supplement form.