When a person is given a toxic dose of a fluoroquinolone antibiotic, they are “floxed”. Fluoroquinolones (FQs) are genotoxic, meaning that prolonged exposure (over 48 hours) will alter DNA and cripple or destroy cells. For some people, a single pill is enough to cause a toxic reaction. Patients suffer from tendinopathy, chronic fatique, microbiome die-off, peripheral and automomic nervous system damage… and the medical community generally turns a blind eye. Patients who have experienced a toxic reaction are diagnosed with psychiatric disorders such as anxiety, depression and hypochondria, or physical ailments such as fibromyalgia or arthritis. Sometimes they are accused of simply being lazy.
FQs are used as a first line of defense against UTIs and sinus infections, but they are so toxic that they should only be given if the alternative is certain death.
If you think you have been floxed, please visit the Floxie Hope Facebook page. You are not alone.
I think this is the most telling link I can provide: on April 17, 2013, less than a year after I was floxed, the FDA revealed that Cipro damages mitochondria and causes neuropathy.
Fluoroquinolones cause DNA damage and oxidative stress to cells:
- Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells
- In Vitro Discrimination of Fluoroquinolones Toxicity on Tendon Cells: Involvement of Oxidative Stress
- Oxidative Stress Induced by Fluoroquinolones on Treatment for Complicated Urinary Tract Infections in Indian Patients
- A Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics
- New insights in extracellular matrix remodeling and collagen turnover related pathways in cultured human tenocytes after ciprofloxacin administration
- Ciprofloxacin: mammalian DNA topoisomerase type II poison in vivo
- Fluoroquinolones destroy sperm cells, demonstrating cytotoxic effects
- Genotoxic Evaluation of the Antibacterial Drug, Ciprofloxacin, in Cultured Lymphocytes of Patients with Urinary Tract Infection
The mechanisms by which fluoroquinolones destroy connective tissue may be better understood as they are being studied as an antifibrotic drug in the treatment of Scleroderma, which is a thickening of connective tissues. It appears that Cipro alters gene expression in connective tissue growth factor — a bad idea for anyone with normal skin, tendons and muscles, and a very good explanation of why many people go from fit and athletic to having to use canes or wheelchairs.
Some fluoroquinolones are phototoxic:
- Inhibition of Human Topoisomerase IIα by Fluoroquinolones and Ultraviolet A Irradiation
- DNA repair inhibition by UVA photoactivated fluoroquinolones
The longer cells are exposed to fluoroquinolones, the more profound the damage:
Fluoroquinolones increase risk of neuropathy:
- Oral fluoroquinolone use and risk of peripheral neuropathy
- FDA Drug Safety Communication: FDA requires label changes to warn of risk for possibly permanent nerve damage from antibacterial fluoroquinolone drugs taken by mouth or by injection
How to reverse the effects of aging on the brain:
Why Floxies need a lot of sleep: